FORMULATION DEVELOPMENT AND EVALUATION OF ACECLOFENAC MICROEMULSIONAbstract
The aim of my present study is to Develop and Evaluate Microemulsion for topical application of Aceclofenac by using oleic acid at different ratios for the treatment of pain. Microemulsion was prepared by water trituration method using oleic acid as oil phase, tween-80 as surfactant and polyethylen glycol-400 as co-surfactant. Different oils, surfactants and co-surfactants were screened to select ideal components of microemulsions with good solubility and excellent skin penetration of Aceclofenac. The solubility of Aceclofenac was highest in oleic acid followed by olive oil, and isopropyl myristate, isopropyl palmitate. Microemulsion-3 (ME-3) was exhibited 98.54±0.26% higher drug content then other formulations. Among all formulations, the highest permeation flux of µg/cm2/hour was observed in of formulation ME-
Brahmaiah Bonthagarala*, Venkatesh Murukutla and Manohar Babu S.
Department of Pharmaceutics, SIMS College of Pharmacy, SIMS Group of Institutions, Mangaldas Nagar, Guntur,-522001, Andhra Pradesh, India
06 April, 2016
06 July, 2016
08 July, 2016
01 August 2016