FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICRO-SPHERES OF SALBUTAMOL SULPHATE BY USING A NATURAL POLYMERAbstract
Salbutamol sulphate (SS) loaded microspheres were prepared by solvent evaporation method with combination of Sterculia foetida gum in various proportions. A total of eighteen formulations were prepared in different oil phases i.e., liquid paraffin and sunflower oil. Those prepared from liquid paraffin L1-L9 and those prepared from sunflower oil were S1-S9. Based on the particle size, entrapment efficiency, drug content,% yield, swelling index, % moisture loss, micromeritic properties batches prepared from sunflower oil showed better results as compared to those microspheres prepared from liquid paraffin. Thus, sunflower oil batches were optimized for further evaluation parameters. From further parameters four formulations were selected i.e., S2, S6, S8, S9. It was confirmed with the results of micromeritic property that all the selected formulations showed good flow property. Release data were analyzed based on best fitting models and all the optimized batches showed good fit to first order, Higuchi kinetics and Korsemeyer-Peppas. Stability studies showed almost negligible changes in particle size, drug content and drug release throughout the study period.
Kavita N. Patil* and Kanchan P. Upadhye
J.L. Chaturvedi College of Pharmacy, Electronic Building, Hingna Road, Nagpur- 440 016, Maharashtra, India
11 June, 2013
11 August, 2013
22 November, 2013
01 December 2013