FORMULATION DEVELOPMENT AND EVALUATION OF POLY AMIDOAMINE (PAMAM) DENDRIMERS AS POTENTIAL CARRIERS FOR ENHANCED TRANSDERMAL DELIVERY OF ITRACONAZOLE GEL FORMULATION
AbstractThe drug of dendrigel, uses dendrimers as medicine carriers. Dendrimers were prepared by divergent growth techniques and were loaded in varying quantities in carbapol 934. To this mixture, itraconazole drug was added and the expression of dendrigel was estimated. Dendrimers were prepared by divergent growth techniques. Estimation parameters like color test, UV spectroscopy, and FTIR. Evaluation parameters for dendrigel were pH, spreadability, thickness, drug content, antifungal exertion, and in vitro release studies. The set dendrigel has better antifungal exertion than another transdermal medicine delivery system because dendrimers enhance the drug’s solubility, which increases the penetration of the drug in the skin. In the present study, an attempt was made to develop dendrimers containing itraconazole as a drug to increase the solubility and penetration of the drug through the skin using the new delivery system for better antifungal application. This will help to increase the solubility and penetration of the drug. It increases the antifungal application of the formulation.
Article Information
43
5025-5049
2444 KB
378
English
IJPSR
Suman *, Ram Narayan Prajapati, Saddam, Shashi Alok and Sateesh Kumar Bharti
Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.
kmsuman9085@gmail.com
23 June 2023
17 September 2023
26 September 2023
10.13040/IJPSR.0975-8232.14(10).5025-49
01 October 2023
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