FORMULATION DEVELOPMENT AND EVALUATION OF SOL TO GEL OCULAR DRUG DELIVERY SYSTEM OF BRIMONIDINE FOR CONJUNCTIVITISAbstract
The purpose of the present research work was to develop ophthalmic sol to gel controlled delivery system of brimonidine, for the treatment of bacterial conjunctivitis having improved patient compliance and better therapeutic efficacy. For that purpose various formulations were prepared and evaluated for their quality parameters i.e. rheological, trans-corneal permeation, ocular irritation studies, microbiological study. The in-vitro release was determined by using modified flow through cell apparatus. The formulation X4Y2D shows very good result regarding to all quality parameters as well as shown sustained and satisfactory release over a period of 12 hours.
Manu Babbar*, Kanchan Kohli and Anil Bhandari
Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur-342001, Rajasthan, India
05 October, 2012
10 November, 2012
25 January, 2013
01 February, 2013