FORMULATION, DEVELOPMENT AND EVALUATION OF SUBLINGUAL ANTI-EMETIC TABLET BY MELT GRANULATION TECHNIQUEAbstract
Prochlorperazine maleate is used for the treatment of motion sickness and classified under BCS class II for treatment of emesis, the per-oral route is preferred route of administration but first-pass effect and poor bioavailability limits its application. To overcome these limitations, efforts were made to enhance the bioavailability of drugs via the development of a sublingual tablet by melt granulation technique. The formulation was developed by the melt granulation method where PEG 6000 and PEG 400 blend and gelucire as a hydrophilic polymer were used to enhance solubility and drug release rate. The tablets were evaluated for hardness, thickness, friability, weight variation, drug content, wetting time, in-vitro disintegration time and water absorption ratio, and in-vitro dissolution studies. It was concluded that sublingual tablets containing sugar: PEG ratio drug, and lactose showed the highest drug release in the in-vitro dissolution studies. The optimized batch was subjected to accelerated stability studies. No change in physicochemical properties as well as in drug content and in-vitro release studies were observed.
R. P. Chitlange * and V. A. Kilor
Department of Pharmaceutics, Gurunanak College of Pharmacy, Nagpur, Maharashtra, India.
23 August 2019
30 December 2020
28 July 2020
01 August 2020