FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF HYDROGEL BASED CONTROLLED RELEASE MATRIX TABLET OF PROPRANOLOL HYDROCHLORIDEAbstract
Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCL is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study hydrogel matrix tablets of anti-hypertensive drug, Propranolol HCL were prepared and evaluated. The HPMC was used as a rate retarding polymer, whereas Talc was used as filler, and magnesium stearate was used as a lubricant. The present study results point out that the rate of propranolol HCL release from HPMC matrices is mainly controlled by the drug: HPMC ratio. When the concentration of HPMC was enhanced, the release of the drug from the matrix tablet was retarded. The prepared hydrogel matrix tablets were evaluated for various parameters like Angle of Repose, Bulk Density, Tapped Density, Carr’s Index, hardness, friability, uniformity of weight, uniformity of drug content, and disintegration studies. The drug-polymer interaction studies were carried out by FTIR studies where it showed that there was no significant interaction. The in-vitro drug release was carried out for all the formulations, and formulation F1 showed about 96% drug release at 12 h. It was concluded that the hydrogel matrix tablet of Propranolol HCL by using HPMC can be prepared to get the desired release of the drug up to 12 h.
A. Talukdar *, H. B. Bayan and M. Islam
NETES Institute of Pharmaceutical Science, NEMCARE Group of Institutions, Mirza, Assam India.
23 March 2020
22 July 2020
28 July 2020
01 March 2021