FORMULATION DEVELOPMENT AND OPTIMIZATION OF HERBAL IMMEDIATE RELEASE TABLET FOR DENGUE

Dengue is the most rapidly spreading mosquito-borne viral disease in the world. Patients with dengue fever are treated symptomatically. There is no specific allopathic treatment for dengue fever. Traditional medicinal plants have been reported to be useful in the treatment of dengue fever. The development of new anti-dengue products from bioactive compounds is necessary to find an effective treatment for dengue. The present work aims at formulation development and evaluation of herbal IR tablets with faster disintegration and good mechanical strength for the treatment of Dengue. Tablets are stable solid dosage forms and are favorable for formulation derived from herbal extracts. The Carica papaya Linn and Boswellia serrata having anti-thrombocytopenic effect, anti-viral and antipyretic effect were used for the development of the nutraceutical tablet. Simple direct compression method was used for the formulation of an immediate release tablet. The effect of various superdisintegrant and diluents was explored. The compressed formulations were evaluated on various pre-compression and post-compression parameters. The tablets were coated with hydroxyl propyl methylcellulose (HPMC) 5 cps to prevent as the drug is hygroscopic. The tablets were subjected to weight variation, hardness, drug content uniformity, friability, wetting time, and In vitro drug release were studied. The results of all evaluation parameters of the nutraceutical tablet were within the acceptable limit. Pre-compression and post-compression studies of nutraceutical tablets show satisfactory results. The in-vitro drug release of Carica papaya Linn and Boswellia serrata from optimized nutraceutical formulation was found to be 96.61% and 97.22%. Significant results were obtained from the present study.