FORMULATION DEVELOPMENT, CHARACTERIZATION, OPTIMIZATION AND IN-VITRO EVALUATION OF CHITOSAN COATED FLEXIBLE LIPOSOMES OF MUPIROCIN FOR TREATMENT OF LACERATIONAbstract
In present era research work has the continuous focus on the formulation development of chitosan-coated flexible liposomes of Mupirocin that has persistent mitigation of laceration. Skin injuries (laceration), an important health problem that needs to be managed properly in order to avoid serious consequences. The current focus in wound therapy is on upholding the moisture balance in the wound bed and protection against pathogenic invasion. Wound dressings in a form of flexible liposomes incorporating antibiotic mupirocin, can be applied to control dermal infections and thereby ensure optimal wound healing. Drug in flexible liposome provides prolonged contact between drug and wounded area, reducing the need for frequent application of wound dressing. Our project aims to develop the chitosan-coated flexible liposomes of Mupirocin in a soya lecithin and edge activators. The drug Mupirocin was analysed through various physio-chemical and analytical parameters like pre-formulation studies, melting point, solubility, calibration curve, FTIR and drug excipient compatibility study. The chitosan-coated flexible liposomes which were prepared by Rota evaporator technique and incorporation into flexible liposomes with a dose 100mg/50 ml. The chitosan-coated flexible liposomes were evaluated by using various parameters like particle size, polydispersity index, percentage yield, encapsulation efficiency, %dug content and in vitro drug release studies. The stability study for all formulations were conducted for 2 months and found to be satisfactory as per requirement. This above novel formulation requires further in-vivo and clinical study then it will able to proof an excellent tool for persistent management of laceration.