FORMULATION DEVELOPMENT OF BMP-NLC ENRICHED GELAbstract
NLC are innovative vehicles introduced to overcome some limitations of SLN. Particularly, NLC, composed of a solid lipid and a certain content of liquid lipid (oil), show improved drug entrapment efficiency and an increased stability during storage with respect to SLN. Furthermore, NLC, maintaining their solid state, can control the API release from the matrix. To formulate Nanostructure lipid carriers of an anti-inflammatory drug Betamethasone Dipropionate. To conduct in vitro Diffusion studies using dialysis membrane. To Ex vivo permeation study using rat skin. To conduct stability studies at 4°C and room temperature and to evaluate entrapment efficiency at various time intervals.
Premanand A. Nighojkar , S. K. Uma Devi , Kiran V. Pund , Rajendra T. Gadakh and Manoj G. Shinde
Vel's College of Pharmacy, Velan Nagar, Pallavaram, Chennai - 600 117, Tamil Nadu, India
05 May, 2012
02 June, 2012
29 August, 2012
01 September, 2012