FORMULATION DEVELOPMENT OF LYOPHILIZED FLOATING BEADS CONTAINING GINGER EXTRACT AND NIGELLA SATIVA OIL
AbstractLyophillized floating beads have been investigated as a possible gastro-retentive dosage forms containing Ginger (Zingiber Officinalis) extract ( ZOE) and Nigella Sativa oil (NSO). Emulsion gelation method was used in preparation of ZOE-NSO entrapped floating alginate beads. Drug content and floating properties of the beads were found to be satisfactory. The results revealed that lyophillized beads showed better floating behaviour (> 8 hrs). The formulations containing sodium alginate at 3% w/v concentration with 30 %w/v calcium chloride for cross-linking and 30 min for curing time presented with optimum drug release (8 hrs) and floating time (>24 hrs). The optimized formulation was subjected to storage at 40 and 50º C / relative humidity of 60% for a period of three months. In vitro release data of the optimized batch presented Higuchi-diffusion and Korsmeyer Peppas models with Non-Fickian release. The data proposed that the prepared lyophilized NSO and ZOE hydrogel beads delivered their active ingredients by diffusion and erosion mechanisms.
Article Information
18
1091-1096
396
1348
English
Ijpsr
Munira M Momin *, Aditee Mishal and Tejaswi Kale
SVKM’S Dr. Bhanuben Nanavati College of Pharmacy, Mithibai Campus, Ville Parle (w), Mumbai, Maharashtra, India
munira_momin@yahoo.com
20 June, 2014
24 September, 2014
16 November, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.6(3).1091-96
01 March, 2015
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