FORMULATION DEVELOPMENT OF LYOPHILIZED FLOATING BEADS CONTAINING GINGER EXTRACT AND NIGELLA SATIVA OILAbstract
Lyophillized floating beads have been investigated as a possible gastro-retentive dosage forms containing Ginger (Zingiber Officinalis) extract ( ZOE) and Nigella Sativa oil (NSO). Emulsion gelation method was used in preparation of ZOE-NSO entrapped floating alginate beads. Drug content and floating properties of the beads were found to be satisfactory. The results revealed that lyophillized beads showed better floating behaviour (> 8 hrs). The formulations containing sodium alginate at 3% w/v concentration with 30 %w/v calcium chloride for cross-linking and 30 min for curing time presented with optimum drug release (8 hrs) and floating time (>24 hrs). The optimized formulation was subjected to storage at 40 and 50º C / relative humidity of 60% for a period of three months. In vitro release data of the optimized batch presented Higuchi-diffusion and Korsmeyer Peppas models with Non-Fickian release. The data proposed that the prepared lyophilized NSO and ZOE hydrogel beads delivered their active ingredients by diffusion and erosion mechanisms.
Munira M Momin *, Aditee Mishal and Tejaswi Kale
SVKM’S Dr. Bhanuben Nanavati College of Pharmacy, Mithibai Campus, Ville Parle (w), Mumbai, Maharashtra, India
20 June, 2014
24 September, 2014
16 November, 2014
01 March, 2015