FORMULATION, EVALUATION AND ESTIMATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE CONVENTIONAL TABLETS IN COMBINED DOSAGE FORM AND ITS COMPARISON WITH MARKETED FORMULATIONS
AbstractOral route of drug administration have wide acceptance up to 50-60% of total dosage forms. Solid dosage forms are popular because of ease of administration, accurate dosage, self-medication, pain avoidance and most importantly the patient compliance. This study was aimed at development of Propranolol hydrochloride and flunarizine dihydrochloride conventional dissolving tablets in combined dosage form. Propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta (1)- adrenergic receptors in the heart, inhibiting sympathetic stimulation and Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity both are effective in the treatment of coexistence of hypertension & migraine
Article Information
35
1200-1209
871
3857
English
Ijpsr
Dipali Malhotra* and Ravi Sharma
Department of Pharmaceutical Analysis, ASBASJSM College of Pharmacy, BELA (Ropar), Punjab, India
dipalimalhotra68@yahoo.com
18 June, 2014
04 February, 2015
15 February, 2015
DOI: 10.13040/IJPSR.0975-8232.6(3).1200-09
01 March, 2015
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