FORMULATION OF MEDICATED CHEWING GUM OF ONDANSETRON HYDROCHLORIDE AND ITS PHARMACOKINETIC EVALUATIONSAbstract
An attempt has been made to formulate new chewing gum device for ondansetron hydrochloride in the form of tablet. The new drug delivery system was obtained, at room temperature, by direct compression using conventional pharmaceutical equipment. The resulting chewing gum tablets comprise a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appearance and flexibility during storage and chewing. Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of ondansetron hydrochloride for by-passing the hepatic first pass effect. Simple diffusion into the medium causes the release of only a small percentage of the drug contained in the medicated chewing gum, while the delivery of the major part of the dose occurs during mastication. In the present study, an attempt has been made to formulate the chewing gum of ondansetron hydrochloride. Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. Better consistency of formulation and faster release of drug in saliva was obtained with glycerol F (III), and Castor oil F (II) but castor oil shows optimum result against glycerol combination, which is formulation II. Urinary excretion profile showed that within the short span of time 1.5 h drug was excreted. Buccal absorption test showed that 85% of drug absorbed within 15 min when available to the buccal mucosa at pH 5.5. Hence, ondansetron hydrochloride chewing gum can be considered as a better formulation for the buccal drug delivery system, in which drug is absorbed buccally and reaches the systemic circulation via jugular vein.
UPENDRA NAGAICH*, VANDANA CHAUDHARY, ROOPA KARKI, AKASH YADAV, PRAVEEN SHARMA
Acharya & B.M. Reddy College of Pharmacy*, Bangalore, (Karnataka), India
5 January, 2010
25 January 2010
28 January, 2010
01 February, 2010