FORMULATION OF NICERDIPINE HYDROCHLORIDE INCLUSION COMPLEX FOR DISSOLUTION ENHANCEMENTAbstract
The purpose of this study was to improve the dissolution rate of poorly soluble Nicardipine hydrochloride with cyclodextrin complexation by using different techniques like physical mixing, solvent evaporation and kneading method. Nicardipine hydrochloride is a calcium channel blocker. It is belonging to BCS class – II having poor solubility and high permeability. It is used to treat Angina having low bioavaibility about 10 – 40% orally is attributed to the hepatic first pass metabolism. The present invention relates to the inclusion complex made by β-Cyclodextrins and the methods for enhancing the bioavailability of Nicardipine hydrochloride. Solid inclusion complexes were prepared by conventional methods like physical mixing, solvent evaporation and kneading techniques. Optimized complex was characterized by using powder X-ray diffractometer and FTIR. Ex-vivo studies showed that the dissolution rate of Nicardipine hydrochloride was significantly improved by the complexation with β-cyclodextrin with respect to the drug alone. Physical mixing method showed highest dissolution rate than the other techniques.
S. Makwana , R. Kharadi and S. Samova *
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
02 October, 2017
05 March, 2018
11 March, 2018
01 July, 2018