FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF FAST-DISSOLVING SUBLINGUAL FILM CONTAINING CLOVE OIL
AbstractClove oil is an essential oil made from the plant, Szygium aromaticum. It is commonly used to help ease digestive issues, relieve pain, and support respiratory conditions. This work aims to determine at what temperature sublingual films are formed most effectively during process. The given temperature batches were manufactured at 75 °C, 80 °C, 85 °C, 90 °C. The sublingual films were prepared by using the solvent casting method, and the materials used, such as Hydroxypropyl methylcellulose E5, and different grades of polyox were previously optimized. The various batches at different temperatures went through characterization regarding the viscosity of the solution before casting as well as film weight and thickness after casting. All other samples used were of 21 mm x 25 mm film. With these given film samples from each batch, surface pH, swelling index, folding endurance, tensile strength, disintegration time, and percent moisture were all tested. Thus, this study showed the optimum temperature for fast-dissolving sublingual films of clove oil to improve bioavailability and ease of administration.
Article Information
35
3516-3521
1369 KB
390
English
IJPSR
Meera Reddy Mayreddy, Srinija Gumudevelli, Radhakrishna Vankayala, Phanindra Vankayala and Sridhar Gumudevelli *
Formulation R & D, Ascent Pharmaceuticals Inc., New York, USA.
gsridhar@ascentpharm.com
27 October 2022
, 03 June 2023
26 June 2023
10.13040/IJPSR.0975-8232.14(7).3516-21
01 July 2023
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