FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF TOPICAL FILM-FORMING SOLUTION FOR TREATMENT OF DIABETIC FOOT ULCERAbstract
Diabetic foot ulcer is one of the leading causes of lower limb amputation and mortality in diabetic patients. Various factors contribute to the manifestation of chronic wounds in diabetic foot, but ischemia, infection, and elevated levels of matrix metalloproteases enzyme are the main factors. Matrix metalloproteases (MMPs) are elevated to as high as 60%. Thus, altering the wound-healing process. This could be substantially decreased by using tissue inhibitors of MMPs. This article focuses on the effects of tissue inhibitors of MMPs in treating diabetic foot ulcers and preventing lower limb amputation diabetic patients.
Ravi Parashar, Kamta Prasad Namdeo and Manoj Kumar *
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.
03 July 2022
23 August 2022
01 September 2022
01 November 2022