FORMULATION, OPTIMIZATION AND EVALUATION OF TRANSDERMAL PATCHES CONTAINING BENIDIPINE
AbstractThe study focused on the formulation, optimization, and evaluation of benidipine transdermal patches to overcome the drug’s low oral bioavailability and short half-life. FTIR analysis confirmed compatibility between benidipine and selected excipients (HPMC K-100, CMC, PEG-400, Tween-20), showing no significant peak shifts. Patches (F1–F12) were prepared by solvent casting with varying polymer concentrations and evaluated for physicochemical properties, all of which were within acceptable limits, indicating good uniformity and mechanical strength. In-vitro release studies showed an initial burst followed by sustained release for 48 hours, with F5 and F7 exhibiting superior drug release. Central Composite Design identified HPMC K-100 and CMC levels as key factors influencing drug release, moisture content, and permeation, with higher polymer concentrations decreasing release due to increased matrix density. Optimization selected F4 as the best formulation, offering controlled release, high drug content, and improved permeation, suggesting strong potential for sustained antihypertensive therapy.
Article Information
13
1815-1827
1429 KB
1
English
IJPSR
Neha Katiyar *, Pankaj Mishra and Pushpendra Kannojia
BIU College of Pharmacy, Bareilly International University, Bareilly, Uttar Pradesh, India.
katiyarneha40@gmail.com
15 January 2026
02 February 2026
05 March 2026
10.13040/IJPSR.0975-8232.17(6).1815-27
01 June 2026
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