FREE RADICAL SCAVENGING POWER POTENTIATES ANALGESIC, ANTI-INFLAMMATORY AND CNS DEPRESSANT ACTIVITY OF ALANGIUM SALVIIFOLIUM WANGAbstract
Alangium salviifolium wang. Family Alangiaceae used as a traditional medicinal plant. The objective of this study was to evaluate the comparative phytochemical and in-vitro antioxidant activity along with analgesic, anti-inflammatory, and central nervous system (CNS) depressant activities of peel and seed extract of Alangium salviifolium fruit. Quantitative phytochemical analysis for total phenolic and flavonoid content measured by Folin-Ciocalteu and Aluminium chloride method was maximum for peel (104.03 ± 0.40 mg of GAE /gm and 34.33 ± 0.24 mg of CAE /gm of dried extract respectively. In the DPPH assay method, total antioxidant capacity and reducing power assay showed significant (P< 0.05) antioxidant activity based on IC50 value. Peel extract significantly (P< 0.01) inhibited writhing (44.44 %) induced by acetic acid in mice compared to seed (37.45 %). The anti-inflammatory activity measured by the carrageenan-induced mice paw edema method was observed to be significant (P< 0.01, P< 0.05) at 2nd, 3rd and 4th hour. The percent inhibition of peel and seed was 34.97% and 35.50%, which was very close to standard Ibuprofen (37.80%). Our investigation also revealed a significant reduction of locomotor activity of mice in open field and hole cross test compared to standard diazepam. A significant (P< 0.01, P< 0.05) decline in locomotion at the doses of 75 mg/kg for peel and seed (6 ± 1 and 0) after 120 min which was less than the standard (8.33±0.33). It could be accomplished that A. salviifolium may be a promising source of natural antioxidant that potentiate different pharmacological actions.
Tripti Rani Paul *, Badrul Islam, Nurunnahar, Khadiza Khanam, Mir Imam Ibne Wahed and Ashik Mosaddik
Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, Bangladesh.
23 February 2022
23 May 2022
29 August 2022
01 October 2022