FRESH JUICE OF DRYNARIA QUERCIFOLIA RHIZOME FOR THE MANAGEMENT OF ARTHRITISAbstract
Drynaria quercifolia rhizome (DQR) ethnomedicinal information shows the traditional usage of this rhizome for the treatment of body and joint pain, diarrhoea, typhoid, cholera, and skin diseases. The fresh juice of rhizome is still being consumed as an energy drink by tribes and localities of Tamil Nadu and Kerala. However, no investigations have been carried out to claim the anti-arthritic activity of DQR to date. In-vitro studies on anti-arthritic effect of the crude extract were performed. In-vitro anti-arthritic activities were evaluated by using elastase, PLA2, hyaluronidase, and proteinase and assays like protein denaturation inhibition, membrane lysis, and NO scavenging activity. Based on the promising in-vitro results, the use of DQR as an anti-arthritic agent may be agreed upon, and further establishment towards the safety and efficacy is conceded. Acute toxicity study revealed NOAEL (No Observed Adverse Effect Level) up to 2000 mg/kg body weight. Oral administration of 1000 mg/kg body weight (crude extract) for 14 days led to the well tolerance level in albino rats.
U. M. Dhanalekshmi, B. Ramya, T. Gowri and R. Srinivasan *
Organic and Bio Organic Chemistry Division, CLRI, Chennai, Tamil Nadu, India.
18 January 2020
24 May 2020
30 May 2020
01 March 2021