FRUITS OF SCINDAPSUS OFFICINALIS ATTENUATES PYLORUS LIGATION INDUCED ULCER IN RATSAbstract
Objective: Scindapsus officinalis has been reported to have antioxidant, analgesic, anti-inflammatory, antibacterial, and antihistaminic activity. Peptic ulcer disease involves inflammation and oxidative stress. So, the present study was carried out to evaluate the potential of hydroalcoholic extract of Scindapsus officinalis fruits as an antiulcer agent. Materials and Methods: In this pharmacological study evaluation of the antiulcer effect of hydroalcoholic extract of Scindapsus officinalis fruits was performed by using pyloric ligation induced gastric ulcers model. Ranitidine (50 mg/kg p.o.) was used as standard. The preliminary phytochemical investigation, estimation of phenolic and flavonoid content and in-vitro antioxidant activity were also estimated. Results: The hydroalcoholic extract of Scindapsus officinalis fruits has a significant effect on scavenging free radicals as found in DPPH free radical scavenging assay and NO scavenging assay. In pylorus ligation induced ulcer model, the plant extract showed gastric ulcer healing effect and gastric antisecretory effect. The high dose of (500 mg/kg) of hydroalcoholic extract of Scindapsus officinalis fruits was more efficacious in reducing ulcer index. The result was supported by morphological and histopathological study findings. Conclusion: The hydroalcoholic extract of Scindapsus officinalis fruits have antiulcer activity, which can be attributed to its antioxidant mechanism of action.
A. Choudhary *, A. Singh, N. Duggal and B. Kumar
Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
26 March 2014
22 May 2014
13 July 2014
01 October 2014