GASTRIC ULCER PROTECTIVE EFFECT OF MADHUCA LATIFOLIA ROXB BARK IN WISTAR RATSAbstract
The present study was carried out to investigate the protective effect of ethanolic extract of Madhuca latifolia (Roxb.) bark (MLE) and aqueous extract of Madhuca latifolia (Roxb.) bark (MLA) in aspirin-induced gastric ulcer. In both extract, acute toxicity performed according to guidelines for the selection of doses. The oral administration (400 mg/kg) of MLE & MLA extract reduced the ulcer index and prevents the development of gastric lesions by 76.57% and 81.14% (% of protection), respectively. The present studies provide preliminary data on the antiulcer potential of bark and support the traditional uses of the plant for the treatment of gastric ulcer.
N. Patel, P. Kumar *, S. Rai, M. P. Singh, R. Pandey, S. S. Shukla, S. Saraf, S. Patel and D. Patel
KIET School of Pharmacy KIET Group of Institutions, Ghaziabad, Uttar Pradesh, India.
23 March 2014
13 June 2014
28 June 2014
01 September 2014