GASTRORETENTIVE SUPERPOROUS HYDROGEL TABLETS OF DEXLANSOPRAZOLEAbstract
Superporous hydrogels (SPHs) were developed to retain the drug in the gastric medium. These systems swell very rapidly in the stomach and maintain their integrity for longer time even in the acidic environment of stomach, while releasing the pharmaceutical active ingredient. The present work focuses on concept of development of superporous hydrogel tablets of Dexlansoprazole, their comparativeness to the marketed delayed release dosage forms. The aim of this study was to prepare Gastroretentive dosage form based on SPH using Dexlansoprazole, a proton pump inhibitor as a model drug for swelling & prolonged drug release characteristics in acidic pH. The formulation is based on preparation of third generation SPHs with three different polymers, such as, sodium alginate, pectin, chitosan and acrylic acid were used with different concentrations by crosslinking technique using formaldehyde as cross linking agent to get the desired sustained release profile over a period of 8-12 hrs. The characterization studies for SPH were performed by measurement of apparent density, porosity, swelling studies, mechanical strength, scanning electron microscopy (SEM) and FT-IR. All formulations were evaluated for stability, drug content, and kinetic drug release & in-vitro drug release profile. It was concluded that the proposed gastroretentive drug delivery system based on SPHs is promising for stomach specific delivery of Dexlansoprazole.
Nikunja B. Pati *, Swapna Velivela, Vinyas Mayasa and V. R. M. Gupta
Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram, Medak, Hyderabad, Telangana, India
03 June, 2016
07 October, 2016
24 October, 2016
01 November, 2016