GASTRPROTECTIVE & ANTI-ULCER ACTIVITY OF SACCHARUM OFFICINARUM FRESH JUICE IN CHEMICAL INDUCED ULCER IN ALBINO RATSAbstract
Objects: In the present study the anti-ulcer activity of Saccharum officinarum fresh juice was investigated in the chemical-induced ulcer. The efficacy of the plant based juice was compared with standard reference anti-ulcer drug Ranitidine. Methods: The fresh juice collected from the plant of S. officinarum. Firstly, washes the sugarcanes well and peel the outer layer of the cane with a big knife. Then cut them into small pieces and squeeze them for extraction. Take out the extract along with them in a big container. And then study with chemical-induced ulcer in healthy rats. Result: The modal of absolute 40% ethanol-induced ulcer, oral administration of fresh juice (20ml/kg/bw) dose showed that reduction in ulcer index, collection of gastric juice, free acidity, total acidity, and also shows the pH of gastric juice and all parameters compared with the control group. It was showing a protection index of 55.99% at the dose of 20ml/kg/bw. Ranitidine as reference standard drug and showing a protection index of 63.32% at the dose of 50mg/kg-bw. Conclusion: The result of the present study reveals that the plant juices are having efficiency in the gastroprotective activity. It is recommended that the above said plant-derived juices could be further studied for their anti ulcer efficacy in human subjects.
R. Singh * and R. Shukla
School of Pharmaceutical Science, Shri Venkateshwara University, Gajraula, Amroha, Uttar Pradesh, India.
15 March 2020
18 June 2020
23 September 2020
01 March 2021