GC-MS ANALYSIS, ANTIBACTERIAL AND ANTICANCER ACTIVITIES OF BARK EXTRACT OF LANNEA COROMANDELICA (HOUTT.) MERR.Abstract
Lannea coromandelica is one of the important herbal plants well distributed in India. It is commonly called as Odiar, Gumphini in South India. It was extensively used by the tribes all over India to treat various diseases such as body pain, tooth ache, stomach ache, ulcers, sexual impotency. The aim of the present study was to evaluate the GC-MS analysis, antibacterial and anticancer activities of methanol bark extract of L. coromandelica. The methanol extract was subjected to GC-MS analysis to find out active volatile and semi-volatile compounds. The antibacterial activity was carried out by well diffusion method by using nutrient broth agar medium. Microorganisms such as Escherichia coli, Staphylococscus aureus, and Bascilus subtilis were used to evaluate antibacterial activity. The maximum zone of inhibition 21 mm was measured for Bascilus subtilis at 500 µg/mL concentration followed by Staphylococscus aureus was 19 mm and Escherichia coli was 18 mm. The anticancer activity was carried out by MTT assay method for MCF7 cell line. The maximum cell death was 74.20 ± 0.71% at 100 µg/mL concentration and the IC50 was 23.83 µg/mL concentrations.
C. Sivaraj *, B. Pavithra, A. Srivastav and P. Arumugam
Natural Product Division, ARMATS Biotek Training and Research Institute, Chennai, Tamil Nadu, India.
21 October, 2017
06 June, 2018
10 June, 2018
01 July, 2018