GENETIC BACKGROUND ASSOCIATED WITH THE PROGRESSION OF NON- ALCOHOLIC FATTY LIVER DISEASE TO LIVER FIBROSISAbstract
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease around the world. Individuals with obesity, diabetes, hyperlipidemia, metabolic syndrome, and insulin resistance are more likely to develop steatosis; however, it seldom progresses to steatohepatitis, fibrosis, and cirrhosis. In addition to the environmental factors, genetic variations further modify NAFLD progression. Several epidemiological, familial, and twin studies have elucidated the role of heritability. More recent genome-wide association studies and candidate gene studies have reported certain genes that play a key role in the susceptibility and advancement of NAFLD. The genetic basis of the disease further enhances the understanding of the pathogenic mechanism, which helps in developing novel biomarkers and therapeutic strategies. This review provides a summary of the genes involved in the susceptibility of NAFLD.
M. Nooreen *, S. Fatima, M. Sultana, Z. Fatima and Z. Unnissa
Department of Pharmacy Practice, Mesco College of Pharmacy, Hyderabad, Telangana, India.
12 January 2020
24 April 2020
27 April 2020
01 January 2021