GUT-MICROBIOME MANAGEMENT: AN ISSUE WORTH CONSIDERING IN COVID-19 TREATMENTAbstract
The human gut is colonized by an inherent group of microorganisms that cohabits with us and plays a critical role in maintaining homeostasis. Evidence is being piled up, showing the roles of gut micro-flora in the severity and consequences of COVID-19. The gut-lung cross talk is thought to mediate this outcome resulting in an alteration of gut-microbiome, a phenomenon known as gut-dysbiosis during the progression of SARS-CoV-2 infection. A destabilization of gut-microbial homeostasis can upset the host immune system causing critical outcomes in COVID-19 patients with preexisting co-morbidities like CVD and diabetes. This review underlies the interaction between gut micro-flora and SARS-CoV-2 infection and the consequent clinical risk factors. While we are still in the hunt for effective medication and vaccine, the administration of prebiotics along with probiotics as a prophylactic treatment for the management of patients with COVID-19 could help reduce the pro-inflammatory state leading to the new insights of novel safeguard.