HEALTHCARE TRANSFORMATION THROUGH PERSONALIZED MEDICINEAbstract
Excessive heterogeneity in the phenotypic expression of drug treatment response and adverse drug reaction is resolute by a complex interaction of multiple hereditary variants and environmental aspects. The complex nature of treatment response greatly increases the need for personalized medicine. Drug metabolizing enzymes show monogenic genetic polymorphism and influence drug response. Cytochrome P450 enzymes have clinically relevant variation in their effects. Understanding the genome, proteome, plus metabolic pathways have improved drug development. The application of pharmacogenomics, the use of biomarkers, the molecular system approach, and metabolomics technology will certainly help in the development of personalized medicine. Proteomic technology requires further development for analyzing a massive amount of genes and protein profile data. There is the need to cheer a paradigm shift from traditional medical practices to personalized medicine. Due to the high prevalence of inherited genetic disorders and non-communicable diseases, personalized medicine has its own significance. It aims to enhance awareness, motivation, and sincere efforts towards better and cost-effectiveness.
U. Shakarwal, D. Srivastava and Z. Fatima *
Amity Institute of Pharmacy, Amity University, Lucknow Campus, Uttar Pradesh, India.
31 March 2020
20 July 2020
28 July 2020
01 March 2021