HEPATOPROTECTIVE ACTIVITY OF ALCOHOLIC AND AQUEOUS EXTRACTS OF ALLIUM CEPA LINN. (LILIACEAE) IN RATSAbstract
In the present study, we have chosen a plant named Allium cepa Linn(Liliaceae) to evaluate its hepatoprotective activity in experimental animals. Different pharmacological activities are reported with different parts of this plant. Some of its medicinal properties reported are as stimulant, diuretic, anti-tubercular, anthelmintic, and used for various diseases like diabetes, skin diseases, rheumatism, asthma, nausea and constipation. From the literature we found that A. cepa has also been traditionally indicated for treatment of hepatic disorders. This prompt us to select bulb extracts of this plant for the study of hepatoprotective activity in paracetamol induced hepatotoxicity in experimental animals. Phytochemical screening of A. cepa revealed the presence of Saponins, carbohydrate, steroids, Flavonoids. The present study was made to evaluate the hepatoprotective effect of alcoholic and aqueous extracts of Allium cepa in CCl4 and paracetamol induced hepatic injury in experimental animals. Hepatoprotective activity of A. cepa was studied by estimating the serum levels of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), direct and total bilirubin. The treatment with AEAC and AQEAC showed significant reduction of CCl4 and paracetamol induced elevated serum enzyme and pigment levels. Histopathology of liver shows hepatoprotective effect of these extracts.
Riyaz Shaik*, R.L. Manisha , Suresh Babu Sayana and Rajesh Pal
Department of Pharmacology, V.L. College of Pharmacy, Raichur-584 103, Karnataka, India
10 May, 2012
19 June, 2012
29 August, 2012
01 September, 2012