HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ACALYPHA COMMUNIS MULL. ARG. AGAINST INTOXICATION OF THIOACETAMIDE AND RIFAMPICIN-INDUCED RATSAbstract
Background: The present study aimed to evaluate the hepatoprotective activity of aqueous extract of Acalypha communis in Wistar rats. Methods: The hepatoprotective activity was studied by Thioacetamide (TAA) (100 mg/kg b.wt.i.p) and Rifampicin (RMP) (100 mg/kg, po) induced models. Acute toxicity studies and preliminary phytochemical screening were also studied to evaluate the toxicity. Results: No toxicity profile was observed in rats after oral administration of the ethanolic leaf extract at 5mg/kg body weight. The different doses of 200 mg/kg and 400 mg/kg were administered with the extract of Acalypha communis; there was significant (P < 0.001) reduction in Biochemical parameters with respect to control. Phytochemical screening of the plant extract revealed the presence of tannins, alkaloids, flavonoids, saponins, and terpenoids. Conclusion: It can be concluded that the hepatoprotective activity elucidated by Acalypha communis could be mainly due to the presence of a high-value class of compound like the phenolic group as the major content in the plant.
T. Muthuramu *, Gopinath, Thressiamma Sebastin, Neethu Murali and K. U. Athira
Department of Pharmacology and Toxicology, KTN College of Pharmacy, Palakkad, Kerala, India.
06 June 2022
24 July 2022
04 August 2022
01 February 2023