HEPATOPROTECTIVE ACTIVITY OF EXTRACTED FLAVONOIDS FROM ORTHOSIPHON STAMINEUS AGAINST HALOTHANE INDUCED HEPATOTOXICITY IN RATSAbstract
Usually, medicine includes the use of herbal medicines, animal parts, and minerals. However, herbal medicines are the most widely used of the three. The general guidelines for policies on Research and Evaluation of Traditional Medicine cover a wide range of issues and are intended to meet the different states in various countries and regions of the world. Orthosiphon stamineus is an herb that is widely grown in tropical areas. It is also known as Orthosiphon aristaeus. The plant can be identified by its white or elaborate colored flowers that resemble cat whiskers. It was found that O. stamineus exhibits diuretic, hypouricemic and renal caring, antioxidant, and anti-inflammatory, hepatoprotective, gastroprotective, anti-hypertensive, anti-diabetic, anti-hyperlipidemia, anti-microbial, and anorexic activities. Liver failure is continually associated with cellular necrosis, increased tissue lipid peroxidation and depletion in the flesh GSH levels. In addition, serum levels of many biochemical markers like SGOT, SGPT, triglycerides, cholesterol, bilirubin, alkaline phosphatase are elevated. Hence in the present study, the best effort is made to evaluate the caring effect of methanolic extract of Orthosiphon stamineus leaves against various hepatotoxic agents in validated rat models.
Narsapuram Bharathi, Ganesh Akula *, Santhosh Suddagoni and M. Venkataramana
Department of Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda, Gajwel, Siddipet, Telangana, India.
05 October 2021
28 December 2021
05 January 2022
01 July 2022