HEPATOPROTECTIVE ACTIVITY OF SCINDAPSUS OFFICINALIS FRUIT IN PARACETAMOL INDUCED HEPATOTOXICITY IN RATSAbstract
Scindapsus officinalis (Roxb.) Schott fruits are widely used in many parts of India for the treatment of various diseases. It is one of the plants used in Indian system of medicine which belongs to family Aracea. It has the significant antioxidant property due to presence of flavonoids and phenolic compound and has ability of cytoprotection due to antioxidant property. Hydroalcoholic extract (50%Ethanol) of Scindapsus officinalis fruit was prepared and evaluated for its hepatoprotective Potential against paracetamol-induced hepatotoxicity in rats. Alteration in the levels of SGPT, SGOT, ALP, bilirubin, total protein and tissue GSH, GSSG and MDA were tested in both treated and untreated groups. SGPT, SGOT, ALP and bilirubin was enhanced significantly (p<0.05) in Paracetamol (2mg/kg B.wt.) treated group and total serum protein, tissue MDA rise and tissue level of GSH was significantly (p<0.05) reduced in Paracetamol (2mg/kg B. wt.) treated group. Pretreatment with Hydroalcoholic extract (50% Ethanol) of Scindapsus officinalis fruit (200mg/kg B. wt. and 400 mg/kg B. wt.) has brought back the altered levels of biochemical markers to the near normal levels. The histopathology of the liver tissue shows liver necrosis and the recovery is significant in HESO treated groups. Silymarin is used as standard drug. All statistics was done on SPSS windows Ver.16.0.
Nikhil Shrivastava*, Preeti Agrawal , Akanksha Khare , Sarlesh Rajput , Rajendra Singh Baghel , Satyendra Singh Baghel
Department of Pharmacology (Toxicology Research Division), Shriram College of Pharmacy, S.R.G.O.C. Campus, AB Expressway Banmore, Madhya Pradesh, India
03 December, 2012
08 February, 2013
29 March, 2013
01 April, 2013