HEPATOPROTECTIVE ACTIVITY OF STEM BARK EXTRACT OF MANGIFERA INDICA L. ON CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY IN WISTAR ALBINO RATSAbstract
The effects of aqueous stem bark extract of Mangifera indica in Carbon tetrachloride induced liver injury were investigated. In vivo animal models using Wistar albino rats was used in this experimental study. Carbon tetrachloride was successfully induced by significantly (P<0.001) increasing serum parameters AST, ALT, and ALP and decreasing serum total proteins and albumin levels (P<0.05). Standard antioxidant drug vitamin C at a dose of 50mg/kg body weight significantly (P<0.05) decreases the elevation of serum enzymes and increases the serum total proteins and albumin levels near to the normal control. It was found that the stem bark extract of M. indica exhibit hepatoprotective properties, as apparently observed from changes in the biochemical parameters by decreasing the elevated serum enzymes AST, ALP, and ALP and increasing the serum total proteins and albumin levels. The results of our present findings suggest that stem bark extract of M. indica provide effective protection against CCl4-induced hepatotoxicity. It is therefore evident that M. indica can serve as a good source of effective antioxidant against liver injury.
Ibrahim Malami*, Muhammad Shamsuddeen Musa , Alhasan M. Alhasan , Muhammad K. Dallatu , Kabiru Abdullahi
Department of Pharmacognosy and Ethnopharmacy, FPS, Usamnu Danfodiyo University, Sokoto, Nigeria
03 November, 2013
13 January, 2014
10 March, 2014