HEPATOPROTECTIVE ACTIVITY OF TUBEROUS ROOT OF IPOMOEA DIGITATA LINN. AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY.Abstract
Hepatitis is major health problem in human being due to various chemical including therapeutic agent and environmental toxin and this can leads to illness like jaundice, which sometime may lead to even death. Ipomoea digitata Linn. is used in ayurvedic formulation for various disease conditions and commonly known as “Vidarikanda”. The present study deals with hepatoprotective activity hydroethanolic extract of tuberous root of Ipomoea digitata Linn. against CCl4 (i.p) induced liver damaged in female Wister rat. The drug was extracted and preliminary phytochemical screening of extract was done then extract was subjected to toxicity study. The hydroethanolic extract of tuberous root of Ipomoea digitata Linn. was administered orally at the dose of 250mg/kg and 500mg/kg .These shows significant protective effect on liver evidenced by lowering serum level of ALT, AST, ALKP, TB, DB, and Serum Triglyceride and also by histopathological study. All result obtain result are compared with standard (Silymarin) and control group. Thus it concludes that hydroethanolic extract of Ipomoea digitata Linn. shows significant hepatoprotective activity prevents chemically induced hepatic damaged in rat.
Dinesh Mali*, Sujeet Singh, Yadunath Joshi, and Vilasrao Kadam
Department of pharmacology, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Navi-Mumbai, Maharashtra, India
01 January, 2011
01 March, 2011
22 March, 2011
01 April, 2011