HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF ABROMA AUGUSTA AGAINST NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN SD RATSAbstract
To study the hepatoprotective activity of ethanolic leaves extracts of Abroma augusta against non-alcoholic fatty liver disease to validate ethnobotanical claim regarding the plant used in the above mentioned disease. Materials and Methods: The hepatoprotective potential of Abroma augusta leaves extract (AALE) (250 and 500 mg/kg/ body weight) was studied on Methionine and Choline deficient diet (MCD diet), High Fat Diet (HFD), Cholesterol and Cholate diet (CCD) and streptozotocin + HFD induced non-alcoholic fatty liver disease. In the last treatment, blood was collected from direct cardiac puncture and analyzed for various parameters like alanine aminotransferase (ALT), aspartate transaminase (AST), triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), free fatty acid (FFA) and malondialdehyde (MDA). Results: The present study showed for the first time that AALE reduced level of ALT, AST, TG, TC LDL, FFA, MDA and possessed hepatoprotective activity as evidenced by its significant inhibition in the formation of hepatoxicity induced by diet and chemical agents with maximum curation (500mg/kg/b.w.) against non-alcoholic fatty liver disease. It enhances the level of SOD, HDL and also reverses hepatic damage towards normal, which further supports the hepatoprotective activity of leaves extracts of A. augusta. Conclusions: The ethanolic leaves extract of Abroma augusta have a significant effect at a higher dose of 500mg/kg.b.w. These findings could justify, at least partially, the inclusion of this plant in the management of Hepatic disorders in traditional medicine.
K. Anil Yadav * and Anoop Singh
Institute of Pharmacy, Pranveer Singh Institute of Technology (PSIT), Kanpur, Uttar Pradesh, India.
12 March 2021
10 September 2021
05 December 2021
01 January 2022