HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF BALANITES AEGYPTIACA (L.) DEL AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATSAbstract
The various parts of Balanites aegyptiaca (L.) Del (Balanitaceae) is used in Ayurvedic and other folk medicine for the treatment of various ailments such as syphilis, jaundice, liver and spleen problem, epilepsy and yellow fever. This study was designed to evaluate the hepatoprotective and antioxidant effect of ethanol extract of aerial part of Balanites aegyptiaca on CCl4 induced hepatotoxicity in rats. Activities of liver marker enzymes, SGOT, SGPT and ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins at an oral dose of ethanol extract of Balanites aegyptiaca (100 and 200mg/kg) showed a significant hepatoprotective effect. Regarding antioxidant activity, ethanol extract of Balanites aegyptiaca exhibited a significant effect showing increasing levels of SOD, CAT, GPX and GRD by reducing malondialdehyde (MDA) levels.
T. Mayba Gnana Suky , B. Parthipan , C. Kingston , V.R. Mohan* and P. Tresina Soris
Ethnopharmacology Unit, Research Department of Botany, V. O. Chidambaram College, Tuticorin, Tamil Nadu, India
17 December, 2010
15 January, 2011
14 March, 2011
01 April, 2011