HEPATOPROTECTIVE EFFECTS OF POLYHERBAL FORMULATION AGAINST CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY IN ALBINO RATSAbstract
Objective: To investigate the hepatoprotective activity of polyherbal formulation composed of extracts of Bauhinia variegata, Oxalis corniculata, and Pterocarpus marsupium. Methods: The hepato-protective activity of the formulation and extracts were assessed on the basis of histopathological changes in the liver and estimation of SGOT, SGPT, SALP, serum bilirubin of carbon tetrachloride-induced hepato-toxic rats. Results: The result of the present studies strongly indicates that the hepatoprotective property of polyherbal formulation is evidenced by less damaged hepatocytes cells. Conclusion: Polyherbal formulation composed of aqueous extracts of Bauhinia variegata, Oxalis corniculata, and Pterocarpus marsupium revealed significant hepatoprotective profile as compared to standard formulation Liv-52.
A. G. Jadhav and R. S. Dhikale *
Department of Pharmacognosy, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India.
28 August 2020
03 February 2021
19 May 2021
01 August 2021