HEPATOPROTECTIVE FUNCTION AS WELL AS SOLUBILITY AND ORAL BIOAVAILABILITY OF NANO-BASED SILYMARIN: A POTENTIAL REVIEWAbstract
Silymarin is a mixture of flavonolignan and polyphenolic bioactive natural products found in the milk thistle plant Silybum marianum. It has anti-oxidant, anti-inflammatory, anti-cancer, and antiviral activities potentially useful in treating several liver disorders, such as chronic liver diseases, cirrhosis and hepatocellular carcinoma. However, the benefits are curtailed by its extremely poor water solubility (<50 μg/mL), low bioavailability and poor intestinal absorption. To solve these problems, nano-based technological strategies appear to be a promising method to potentiate therapeutic action. The purpose of this study is to review the different nanostructured systems available in the literature as delivery strategies to improve the absorption and bioavailability of silymarin.
Jyotirmoy Bhattacharyya *, Abdul Baque Ahmed and Sumit Das
Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical, Science, Azara, Hatkhowapara, Guwahati, Assam, India.
04 August 2020
03 July 2021
07 August 2021
01 October 2021