HEPATOPROTECTIVE POTENTIAL OF POLYHERBAL PREPARATION AGAINST CCl4-INDUCED LIVER TOXICITY IN RATSAbstract
Hepatoprotective activity of Polyherbal preparation against CCl4 ‑induced hepatic damage in rats was observed. The healthy control (normal), control, and standard drug Silymarin treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALP and total Bilirubin were assessed in all the experimental groups. The changes in liver function parameters were significant in comparison to control group and the observed efficacy was comparable to standard drug. The efficacy of the polyherbal preparation was found to be dose dependent. From the present study it is evident that the Polyherbal preparation has no mortality in selected doses. Liver antioxidant markers were elevated significantly, while the serum and lipid parameters were maintained at normal levels compared to control groups. Histopathological examinations of the liver showed that extract and Silymarin have a protective role over the toxicity of paracetamol and carbon tetrachloride induced hepatotoxicity in rats. Hence Polyherbal preparation could be one of the best sources of natural hepatoprotective agents.
Sarika Shrivastava * and Ritu Gilhotra
School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.
12 September, 2016
07 February, 2017
17 February, 2017
01 March, 2017