HERBAL DRUG LOADED NANOGEL FOR EFFECTIVE TREATMENT OF SKIN DISORDERS

Since ancient times, plants have been used for medicinal purposes for their various therapeutic potentials and safest to modern allopathic medicines. Regularly phytochemicals are proving to be modern medicine with novel drug delivery systems by treating different diseases and disorders. Phytochemical compounds need improvement of efficacy and patient’s compatibility to deliver in various diseases, e.g., high blood pressure, microbial, coronary heart disease, cancers, diabetes, inflammation, etc., also require a rational approach. Nanotechnology is a promising drug delivery approach for targeted or site-specific phytoconstituent delivery. Especially, Nanogels are the most rational approach for targeting skin diseases and enhancing bioavailability. Phytoconstituents or plant extract-loaded nanogels have been reported in in-vitro and in-vivo activities for different skin disorders like aging, acne, skin infection, etc. Nanogels, as a novel drug delivery system, may reduce toxicity and improve the bioavailability of the incorporated drug. The present review is focused on various phytomedicines that have been used in treating skin aging and acne, nanogel formulations prepared, and the effectiveness of both phytochemicals and nanotechnology for skin disorders treatment.