HETEROCYCLE-FUSED BENZIMIDAZOLE: A PRIVILEGED SCAFFOLD IN ANTIMICROBIAL DRUG DISCOVERYAbstract
Compounds with heterocyclic moiety are important for life and are abundant in nature. Heterocyclic compounds have a crucial part in the metabolism of all biological cells. Humanity relies heavily on nitrogen-based heterocyclic compounds. Benzimidazole, in particular, is a vital component of the entire nitrogen-based heterocyclic chemical family, not just physiologically but also industrially. Because once benzene, as well as imidazole, get merged around each other, a heterocyclic benzimidazole compound forms. Benzimidazole incorporates two nitrogens like a heteroatom. Benzimidazole analogues are often more powerful, medicinally significant chemicals with a wide range of biological activities. Benzimidazole analogues have been proven to be beneficial in several fields. The medicinal characteristics of benzimidazole analogue are diverse, including anticancer, antidiabetic, antihypertensive, and antimicrobial properties. Because of the medications’ uses in the treatment of microbe-related infections and other biological activities, stronger and more significant pharmaceuticals are being developed. These compounds have been found to be efficient against various bacteria in pharmacological tests. The antimicrobial property of several benzimidazole compounds is summarised in this study.
Sugat Shukla, Arun Kumar *, Shikhar Verma and Kuldeep Singh
Faculty of Pharmacy, Integral University Kurshi Road, Lucknow, Uttar Pradesh, India.
29 May 2022
09 July 2022
03 August 2022
01 February 2023