HISTOLOGICAL STUDY OF THE EFFECT OF MALATHION ON LIVER AND KIDNEY TISSUES OF MICE MODEL

Malathion is a widely used organophosphorous pesticide that a large number of populations are undesirably exposing themselves to severe health risk due to taking up the contaminated foods, water and vegetables containing malathion. The present study was carried out through histopathologic test to evaluate the extent of damage caused by malathion in the liver and kidney tissues of mice. Twenty five adult female albino mice were used and dispense mainly into two groups as control group and treatment group. The mice of control group were feed with poultry food without any ingredient of malathion. Each of the treatment groups (group1, group 2, group 3 and group 4, containing five animals in each group) were supplied everyday with the same type of food containing the following amounts of malathion as 65mg, 13mg, 2.6mg, and 0.52mg per 50gm (10gm food/mouse) of food, respectively. After fifteen days the animals of both groups were sacrificed and the organs of sacrificed animal were subjected to histopathological examination and then visualized under light microscope. Results demonstrated various histopathological alterations such as enlargement of the sinusoids and vacuole formations in hepatocytes and central vain, congestion of blood vessels of hepatic tissue, hemorrhage and necrosis in hepatic tissue and swelling appearances, highly degeneration and shrinkage of glomeruli, Bowman’s capsules and related tubules structure, edema of renal tubules and rising of urinary space in renal tissue compared with their control. Therefore, we strongly recommend here for the ban of malathion for used as pesticide.