HISTOPATHOLOGIC EFFECTS OF C. METULIFERUS E MEY (CUCURBITACEAE) FRUITS IN ALBINO RATSAbstract
The fruit extract of C. metuliferus was evaluated for its phytochemical and histopathologic properties. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, sterols, saponins and cardiac glycosides. The histopathological effects of C. metuliferus fruit extract on the liver, kidney, spleen and pancreas of male adult albinos rats were investigated after daily oral administration for 28 days. The histological examination of rats administered 1000mg/kg of C. metuliferus fruits extract showed focal hepatocellular necrosis similar to that produced by paracetamol overdose. Necrosis of the epithelial cells of the kidney tissues was also observed in rats administered 1000mg/kg of C. metuliferus fruit. These observations suggest that daily oral administration of 1000mg/kg of C. metuliferus fruit extract for 28 days was associated with tissue damage of liver and kidney of the rats.
N.S. Jimam*, N. N. Wannang , J. A. Anuka , S. Omale , K. D. Falang , and A. A. Adolong
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Nigeria
21 April, 2011
30 May, 2011
22 July, 2011
01 August, 2011