HISTOPATHOLOGICAL EFFECT OF ETHANOLIC EXTRACT OF TRIDAX PROCUMBENS ON KIDNEY OF ALBINO RATSAbstract
Herbal drugs are emerging as a leading area for new drug discovery and development, and are being looked at seriously for health problem. Plants, especially used in Ayurvedic can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and or reduced toxicity. Exposure of toxicants manifests variety of pathological lesions in various organs depending upon its dose and the period of treatment. Tridax procumbens has been found to possess various significant medicinal properties. Present study is therefore done to study the histological changes on Kidney of albino rats due to effect of ethanolic extract of Tridax procumbens; orally at a single and daily administration of doses at 300mg/kg b.wt and 600mg/kg b.wt for intervals of 7, 14 and 21days. It is quite obvious that its administration may also affect the cellular organization of vital organs. After treatment period there was alterations occurred in histoarchitecture of kidney and it showed remarkable changes in cortex and medullary region.
Vinita Ahirwar*, Shailendra K. Gaur and Kusum Singh
Department of Zoology, Institute of Basic Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India
08 October, 2013
18 February, 2014
03 May, 2014
01, June 2014