HOMOLOGY MODELLING, SECONDARY STRUCTURE PREDICTION AND PHYLOGENETIC COMPARATIVE ANALYSIS OF PHOSPHOLIPASE A2FROM DIFFERENT ORGANISMSAbstract
Phospholipase A2 is the enzyme that catalyzes the hydrolysis of the sn-2 fatty acyl bond of phospholipids, liberating free fatty acids and lysophospholipids. These enzymes are found in mammalian tissues, insects, reptiles, urochordates, invertebrates and echinoderms. Some of the PLA2 are toxic in nature. Venom from snakes and insects is largely composed of melittin, which is a stimulant of PLA2. In this study, Phylogenetic relationship of Phospholipase A2 were compared, tertiary &secondary structures of PLA2 in different species like Apismellifera, Najaatra, Varanusscalaris, Asterinapectinifera, Mesobuthustumulus, Rophilemanomadica were predicted.
K. Aparna*, C. Joyce Priyakumari and J Gladies Kezia
Bioinformatics Centre of BTIS net, Madras Christian College, Chennai, Tamil Nadu, India
17 June, 2014
28 August, 2014
17 October, 2014
01 February, 2015