HYDROETHANOLIC EXTRACT OF CEDRELA ODORATA IMPROVES HYPERLIPIDEMIA AND REDUCES THE ACTIVITY OF ENZYMES IN THE LIVER OF ETHANOL-INDUCED HYPERLIPIDEMIC RATSAbstract
Hydroethanolic extract of the Cedrela odorata (HeECo) showed hypolipidemic potential in diabetic rats. Thus, we evaluate the hypolipidemic effect and the mechanism of the action of the HeECo in a rat model of ethanol-induced hyperlipidemia. Male Wistar rats are divided: normolipidemic (C); hyperlipidemic non-treated (Hl); hyperlipidemic treated with HeECo 500 mg.kg-1 (HlCo); and hyperlipidemic treated with fenofibrate 200 mg.kg-1 (HlFen). The relative weight, lipid content of some tissues, serum lipid profile, enzymatic activity and content of lipase lipoprotein (LPL) in retroperitoneal white adipose tissue (retWAT) were measured. Protein content of SREBP-1c and enzyme activities of glucose-6-phosphate dehydrogenase (G6PD), malic enzyme and ATP-citrate lyase (ACL) were measured in the liver. We observed an increase in the levels of triacylglycerol, total cholesterol and VLDL in the Hl group that the C group. The HlCo group showed reduced serum parameters, relative weight, lipid content and LPL activity in retWAT, that the Hl group. We observed lower activity in G6PD and ACL in the HlCo group that the Hl group. We suggest that HeECo has a hypolipidemic effect, possibly reducing de novo fatty acid synthesis in the liver.
E. W. Allebrandt Neto, S. F. Santos, F. H. S. Silva Gomes, C. V. Santos, M. I. Watanabe, M. A. Giordani, N. H. Kawashita and M. P. Pereira *
Universidade Federal de Mato Grosso, Departamento de Química, Cuiabá, Mato Grosso, Brazil.
18 May 2022
06 September 2022
19 January 2023
01 February 2023