HYDROGEN PEROXIDE SCAVENGING ACTIVITY OF OXAZOLE DERIVATIVES
AbstractThe present study is reported the antioxidant activity of oxazole derivatives. Oxazole are five-member heterocyclic ring containing nitrogen and oxygen as a hetero atom. Due to binding with a wide spectrum of receptors and enzymes easily in biological systems through various non-covalent interactions, oxazole-based molecules are becoming a kind of significant heterocyclic nucleus, which have received attention from researchers globally, leading them to synthesize diverse oxazole derivatives. Oxazole have been reported to possess diverse biological activities like antimicrobial, antiviral, anti-inflammatory and anticancer activity. In this research work some heterocyclic like 4-(substituted benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one with potent derivatives for 100 ug/ml are 4-(4-methylbenzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-7), 4-(3-bromo-4-hydroxy-5 methoxybenzylidene) -2-(pyrazin-2-yl)oxazol-5(4H)-one (PA-13) and are 4-(5-Oxo)-2- (pyrazin-2-yl) 4(5H)-ylidene) methyl) benzonitrile (PA-15) and for 200 ug/ml 4-(4-fluoro benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-4), 4-(4-hydroxy-3-methoxy benzylidene)-2- (pyrazin-2-yl) oxazol-5 (4H)-one (PA-8) and 4-(3-bromo-4-hydroxy-5 methoxybenzylidene) -2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-13) shows promising anti-oxidant activities. The method mainly used as hydrogen peroxide radical scavenging activity. Antioxidant scavenging effect of synthesized derivatives also compared with standard Ascorbic acid.
Article Information
12
5669-5675
903 KB
156
English
IJPSR
Amol Pund, Vilas Ghawate * and Chetan Kedari
Mula Education Society’s College of Pharmacy, Sonai, Ahmednagar, Newasa, Maharashtra, India.
ghawatevilas@gmail.com
10 April 2023
12 June 2023
04 July 2023
10.13040/IJPSR.0975-8232.14(12).5669-75
01 December 2023