Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. It is commonly asymmetrical, with the most severe hypertrophy involving the basal interventricular septum. The histological features of HCM include myocyte hypertrophy and disarray, and interstitial fibrosis. Hypertrophy is also frequently associated with left ventricular diastolic dysfunction. It is also an important cause of sudden cardiac death, particularly in adolescents and young adults. Non-sustained ventricular tachycardia, syncope, a family history of sudden cardiac death, and severe cardiac hypertrophy are major risk factors for sudden cardiac death. Atrial fibrillation is also a common complication and is not well tolerated. Mutations in over a dozen genes encoding sarcomere-associated proteins cause HCM. MYH7 and MYBPC3, encoding β-myosin heavy chain and myosin-binding protein C, respectively, are the 2 most common genes involved.
P. Soni Dixitha *, M. Vijaya Bhargavi and M. Sumakanth
Department of Pharmaceutical Chemistry, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad, Telangana, India.
05 December 2021
08 January 2022
28 April 2022
01 August 2022