HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY OF SOLANUM NIGRUM IN ALLOXAN INDUCED DIABETIC ALBINO RATSAbstract
The objective of this study is to induce experimental diabetes mellitus using Alloxan monohydrate in normal adult albino rats and study the anti‐diabetic activity of changes in body weight, consumption of food and water, volume of urine and levels of glucose between normal and diabetic rats. Diabetes mellitus (DM) is a common endocrine disorder. Hypoglycemic agents from natural and synthetic sources are available for treatment of diabetes. Indian medicinal plants have been found to be useful to successfully manage diabetes. The effect of methanolic and water extract of Solanum nigrum leaves was investigated in normal, glucose load conditions and Alloxan monohydrate ‐induced diabetic rats. Significant hypoglycemic activity was exhibited by the poly herbal formulation.
Arumugam Sengottaiyan*, L. Praburaman , Koildhasan Manoharan , Rathika Rajinikanth , Muthusamy Govarthanan and Thangaswamy Selvankumar
Department of Biotechnology, Mahendra Arts & Science College, Kalipatti- 637501 Tamil Nadu, India
24 April, 2012
14 May, 2012
21 July, 2012
01 August, 2012