HYPOGLYCEMIC EFFECTS OF LUFFA ACUTANGULA (L.) ROXB. FRUIT EXTRACT IN NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATSAbstract
Luffa acutangula (L.) Roxb. (Family: Cucurbitaceae) has been used in the folkloric Indian medicinal system to treat numerous health conditions. The fruits of the plant have been used in dysentery, jaundice, diabetes, hemorrhoids, leprosy, and ringworm infection. The present study aimed to establish the hypoglycemic effect of the aqueous fruit extracts of Luffa acutangula was investigated in normal, glucose load conditions and streptozotocin (STZ)-induced diabetic rats. In normal rats, the aqueous extract of the fruit of L. acutangula (50 and 100 mg/kg/p.o.) significantly (P < 0.001) reduced the blood glucose levels from 65.2–49.4 and 68–48 mg% 2 h after oral administration of fruit extract and also significantly lowered the blood glucose in STZ diabetic rats from 67–101 and 64–89.2 mg% 21 days after daily oral administration of the extract (P < 0.001). The results suggested that the aqueous fruit extract of L. acutangula has a potential hypoglycemic effect in diabetic rats and authenticates the folkloric use of the plant for the management and treatment of diabetes.
R. Thatchinamoorthi *, K. Ganesan and M. R. Pandian
PG Research Department of Biotechnology & Microbiology, National College (Autonomous), Tiruchirappalli, Tamil Nadu, India.
03 April 2020
16 August 2020
05 October 2020
01 April 2021