HYPOLIPIDEMIC AND HEPATOPROTECTIVE EFFECTS OF DIFFERENT FRACTIONS OF METHANOLIC EXTRACT OF MOMORDICA CHARANTIA (LINN.) IN ALLOXAN INDUCED DIABETIC RATSAbstract
The study was undertaken to investigate the hypolipidemic and hepatoprotective effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of methanolic extract of Momordica charantia. The different fractions of extract were administered intraperitoneally as a single dose of 150 mg/kg body weight to alloxan induced diabetic rats and found to reduce blood lipid level (Total cholesterol and Triglycerides) significantly (p<0.05). The plant fractions also exhibited correction of altered biochemical parameters viz., SGOT and SGPT levels in diabetic rats. The effect of plant fractions were compared with standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpenes, alkaloids and flavonoids etc. were present in the plant which has hypolipidemic and hepatoprotective properties. Thus, this study indicates that various fractions (Petroleum ether, ethyl acetate and chloroform) of the methanolic extract of Momordica charantia have favorable effect in hypolipidemic and hepatoprotective activities.
M. S. Hossain, M. Ahmed and A. Islam *
Ph. D, Assistant Professor, Department of Pharmacy, Bangladesh University, 15/1, Iqbal Road, Mohammadpur, Dhaka, Bangladesh
04 November, 2010
29 January, 2011
17 February, 2011
01 March, 2011